cirs, chronic inflammatory response syndrome, mold, mold illness, lyme, chronic illness, breast implant illness, bii, explant, en bloc, SIBO, parasites, gut healing, leaky gut, allergies, food sensitivities

Do you have CIRS?

What is CIRS?

Chronic Inflammatory Response Syndrome, or CIRS for short, is a medical condition more commonly known as mold illness. The research on CIRS started with studying sepsis, which is often a life-threatening condition. The trigger is usually a bacterial infection of some sort that leads to a cascade of inflammatory molecules that cause the majority of its manifestations. It is an acute syndrome that starts with kindling that triggers a fully-fueled fire. It is the innate immune system gone haywire. The lasting effects are chronic inflammation – a fire that is eating up the body, despite the original kindling no longer being present.

The first step in the discovery of CIRS in relation to mold was when Dr. Shoemaker asked the questions: could an inflammatory cascade similar to sepsis be occurring with some of the chronically ill patients we see? Could the fire of inflammation be responsible for many of their chronic and seemingly unrelated symptoms? Dr Shoemaker later realized that virtually the same inflammatory process the occurs in sepsis also occurs in patients who have been exposed to a water-damaged building or who have a chronic illness after suffering from Lyme disease. The mechanism of this illness was discovered later as Dr Shoemaker took the research on human leukocyte antigen (HLA) genetics a step further to explain its role in the development of CIRS.

As a result of Dr Shoemaker’s work, we now know that:

  • Around 95% of the time, CIRS typically occurs in people who have a specific susceptibility in their HLA DQ/DR genes
  • After exposure to biotoxins rather than mounting a proper immune response, people with impaired HLA genetics develop a chronic and ineffective inflammatory response.
  • This inflammatory response is never effective at ridding the body of the biotoxins and dysregulates hundreds of genes ultimately causing a plethora of symptoms.
  • Binding agents such as cholestyramine can allow the body to rid itself of biotoxins however in many cases specific steps to re-balance the inflammatory response are still needed.

So what exactly do we mean by inflammation? Inflammation is actually something that occurs in our body every day as we heal from injuries. For example, if you were to accidentally slam your finger in a door jam you would experience redness, pain, and swelling. These symptoms are caused by pro-inflammatory cytokines which are released by white blood cells. They are the body’s attempt to heal the damage. In CIRS this kind of inflammation is going on deep inside the body, but it doesn’t get switched off, as the body is not able to heal due to genetics.

Dr. Gupta calls the mechanism for development of CIRS is a chaotic and inefficient inflammatory cascade of immune system events as a response to a biotoxin, whether it’s due to mold toxins, toxins from bacteria or parasites that cause Lyme, or some other exposure. It’s chaotic because it involves so many different elements. It’s inefficient because ultimately it doesn’t rid the body of biotoxins. The chaotic inflammatory process further triggers hormonal, neurological, genomic and other imbalances and a broad range of general body symptoms.

The most common symptoms of CIRS include:

  • Fatigue, weakness
  • Feeling unwell after exercise
  • Memory problems, difficulties with concentration and with getting things done
  • Disorientation and confusion
  • Headaches or irregular body pains
  • Vertigo, light headed
  • Muscle aches, cramping, joint pain without inflammatory arthritis
  • Hypersensitivity to bright light, blurred vision, burning or red eyes, tearing
  • Cough, asthma-like symptoms, shortness of breath at rest
  • Chronic abdominal problems including nausea, cramping, diarrhea, or constipation
  • A propensity to experience static shocks
  • Fast or irregular heart beats
  • Fine tremor, such that if you place a piece of paper above your hand when outstretched, the paper will quiver.

To diagnose CIRS a person will likely have (but not always) the following factors present :

  • multisystem, multi-symptom illness (this means that if you only have one predominant symptom such as fatigue, or shortness of breath your illness is not likely to be CIRS. CIRS causes widespread bodily dysfunction, not isolated bodily dysfunction).
  • Current or past evidence of biotoxin exposure (usually this is an exposure to a water-damaged building, but there are other sources too).
  • In 95% of cases evidence of genetic susceptibility (checked with HLS DQ/DR testing).
  • Positive Visual Contrast Sensitivity (VCS) test (not essential).
  • Blood tests showing the typical inflammatory and hormonal changes associated with CIRS.

Generally speaking, a person with CIRS will tend to have some symptoms from at least six symptom clusters; and commonly will have up to ten symptom clusters:

CIRS table

It is important to note that CIRS is not just a condition associated with mold. Biotoxins are small compounds that can be in a moldy water damaged building and inside saline breast implants, from bacteria or parasites that cause Lyme disease, or even a spider bite. Approximately 25% of the population have a genetic susceptibility that makes them unable to mount a proper immune response to these biotoxins.

Dr Shoemaker has found that those with this genetic susceptibility often have had a severe inflammatory event, or cytokine storm in their past that primes their HLA genes. This can be due to things like mononucleosis, Coxsackie, or ECHO viral infections, inflammatory lung responses or Lyme disease. Accidents, surgery and extreme stress could also be triggering events. Once a primed HLA susceptible individual gets exposed to enough biotoxins an inflammatory response occurs, which causes and excess of inflammatory compounds called cytokines to be produced. Pro-inflammatory cytokines in CIRS turn on the fire of inflammation, inflaming certain tissues of the body and cause the immune system to become compromised. They also cause dysfunction of the complement pathway, which are comprised of proteins used by the immune system to eliminate pathogens and toxins.

How does this relate to breast implant illness?

Someone with saline breast implants can be a particularly high risk for developing CIRS. Saline implants have a valve used to fill them during implantation that is only supposed to go in one direction. If this valve gets damaged during a fall, or car accident, or blunt force to the breasts it can let mold and bacteria inside. For someone who is genetically susceptible and has had recent exposure to mold, this can become a nightmare as the mold can no longer be escaped. You can move out of a water damaged building, but once it’s inside your implants, moving won’t do you any good. It is literally growing inside of you and releasing biotoxins into the body constantly. In this scenario, the implants themselves can act as the trigger to prime the HLA gene and removing them becomes imperative to restoring health.

Having silicone breast implants does not mean you won’t be susceptible to developing CIRS. The mechanism is different, but it does happen. In both scenarios the implants themselves can act as the trigger that primes the HLA gene. But that’s not all. Exposure to Lyme bacteria and parasites can also be part of the picture. As a result of immune dysregulation caused by breast implants, the immune system can no longer keep Lyme pathogens at bay, which can prime the HLA gene as well. Once the gene is primed, and the susceptible individual is exposed to enough lyme and mold biotoxins (such as living or working in a water damaged building), a cascading inflammatory process begins to occur.

How is CIRS treated?

The first step is avoidance of any ongoing biotoxin exposures and for someone with breast implants, that means getting them removed. If there is water damage or known mold in your work or living situation, it also means properly addressing that. The next step is detoxification of accumulated biotoxins via the use of binding agents. The final steps involve the correction of the hormonal, inflammatory and gene imbalances associated with CIRS.

In summary, genetic susceptibility with priming from an inflammatory event (breast implants, mono, Lyme, extreme stress, surgery, accident, etc) plus exposure to biotoxins causes a person to have a chaotic inflammatory response that causes a whole host of abnormalities, leading to a multi-system, multi-symptom disorder we call CIRS.

If you think this might be part of the puzzle in your chronic illness related to your breast implants, a quick and easy test you can do is the VCS test. You can do this test online at It isn’t 100% accurate and should not be used as a sole diagnostic tool, but it is a good starting place. It will be able to tell fairly accurately if biotoxins are an issue for you. I know this is probably a little overwhelming, which is why it is important to work with a qualified practitioner.

If you’d like to have a discussion about our comprehensive BII healing program that also includes detox as part of the work, please schedule your Breakthrough call HERE.

breast implant illness

Sarah has a passion for health that has taken her along a path from RN, to fitness enthusiast, to becoming a certified Functional Diagnostic Nutrition® Practitioner and True Cellular Detox™ Practitioner. She has a passion for breast implant illness and teaching her clients about restoring health through nutrition, lifestyle, and detox, and guiding them through the sea of mis-information in hopes of finding their path to vibrant health.
Sarah’s belief is that we should settle for nothing less than vibrant health! And with breast implant illness, detoxing after en bloc explant is a foundation for that. She focuses on healing the body naturally at the cellular level with whole(real) foods, lifestyle changes, detoxing, and addressing the downstream conditions caused by breast implants. She believes that alternative therapies can be just as effective, if not more so, than conventional medical treatments because we are seeking to heal the body rather than merely mute a symptom with a pill. Sarah is an advocate for natural living and doing what she can to keep toxins out of the home and environment. She is also very passionate about eating real foods as she feels it’s the key to keeping our health and the future health of our children. The thought of explant surgery and healing the body can be overwhelming, so she is here to guide you through the process. Sarah is super passionate about this work, as she truly believes there is a reason for her own struggles that is bigger than her. Sarah will show you how to reverse breast implant illness, take back your health, and live vibrantly!

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